SJIA and AOSD
Not an actual patient. Individual results will vary.
SJIA and AOSD, which often present similarly, are the juvenile and adult forms of Still’s disease1-4
| SJIA1 | AOSD1,2 |
Patients <16 years Typical age of onset is 1 to 5 years | Patients ≥16 years Typical age of onset is 16 to 35 years |
Signs and Symptoms
Fever, rash, and arthritis/arthralgia are the most common symptoms of Still’s disease1,2
| SJIA1 | AOSD2 | |
| Fever | Occurs daily or twice daily | Occurs daily or twice daily, lasting <4 hours |
| Temperature may spike to ≥39 °C (≥102.2 °F) with a return to normal or to below baseline temperature | Temperature may spike to ≥39 °C (≥102.2 °F) | |
| Rash | ||
| Transient, salmon-pink colored, macular, or maculopapular | Evanescent, salmon-pink colored, maculopapular | |
| Typically found on the trunk, neck, and proximal extremities | Typically found on the trunk and proximal extremities | |
| Arthritis/Arthralgia | Can range from oligoarticular to polyarticular patterns | Arthritis may be symmetrical, with most developing polyarthritis with fever spikes |
| Primarily affects wrists, knees, and ankles | Primarily affects wrists, knees, and ankles |
Left Image Credit: Reproduced with permission from Gabriella Giancane et al, IL-1 Inhibition in Systemic Juvenile Idiopathic Arthritis. Front Pharmacol. 2016;7:467. Figure 1.
Right Image Credit: Reproduced with permission from DermNetNZ.org.
Overlapping features and symptoms with other conditions, such as autoimmune diseases,
may lead to a delay in diagnosis or a misdiagnosis.1,2
AOSD, adult-onset Still’s disease; SJIA, systemic juvenile idiopathic arthritis.
References: 1. Lee JJY, Schneider R. Systemic juvenile idiopathic arthritis. Pediatr Clin North Am. 2018;65(4):691-709. doi:10.1016/j.pcl.2018.04.005 2. Efthimiou P, Paik PK, Bielory L. Diagnosis and management of adult onset Still’s disease. Ann Rheum Dis. 2006;65(5):564-572. doi:10.1136/ard.2005.042143 3. Rossi-Semerano L, Koné-Paut I. Is Still’s disease an autoinflammatory syndrome? Int J Inflam. 2012;2012:480373. doi:10.1155/2012/480373 4. Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Sève P. Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart. Immunol Res. 2015;61(1-2):53-62. doi:10.1007/s12026-014-8561-9
References: 1. Lee JJY, Schneider R. Systemic juvenile idiopathic arthritis. Pediatr Clin North Am. 2018;65(4):691-709. doi:10.1016/j.pcl.2018.04.005 2. Efthimiou P, Paik PK, Bielory L. Diagnosis and management of adult onset Still’s disease. Ann Rheum Dis. 2006;65(5):564-572. doi:10.1136/ard.2005.042143 3. Rossi-Semerano L, Koné-Paut I. Is Still’s disease an autoinflammatory syndrome? Int J Inflam. 2012;2012:480373. doi:10.1155/2012/480373 4. Jamilloux Y, Gerfaud-Valentin M, Martinon F, Belot A, Henry T, Sève P. Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart. Immunol Res. 2015;61(1-2):53-62. doi:10.1007/s12026-014-8561-9