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Mechanism of Action
Not an actual patient. Individual results will vary.
ILARIS neutralizes IL-1β activity1
IL-1β is a critical driver of diseases under the banner of PFS (FMF, HIDS/MKD, TRAPS, and CAPS)2-5
Preclinical activity may not correlate with outcomes.
ILARIS is a recombinant, human anti-human-IL-1β monoclonal antibody1,6
| ILARIS Binds To: | ILARIS Does Not Bind To: |
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References: 1. Ilaris. Prescribing information. Novartis Pharmaceuticals Corp. 2. Jesus AA, Oliveira JB, Hilário MO, et al. Pediatric hereditary autoinflammatory syndromes. J Pediatr (Rio J). 2010;86(5):353‑366. doi:10.2223/JPED.2015 3. Church LD, Cook GP, McDermott MF. Primer: inflammasomes and interleukin 1β in inflammatory disorders. Nat Clin Pract Rheumatol. 2008;4(1):34‑42. doi:10.1038/ncprheum0681 4. Lin Y‑T, Wang C‑T, Gershwin ME, Chiang B‑L. The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. Autoimmun Rev. 2011;10(8):482‑489. doi:10.1016/j.autrev.2011.02.001 5. Lachmann HJ, Quartier P, So A, Hawkins PN. The emerging role of interleukin‑1β in autoinflammatory diseases. Arthritis Rheum. 2011;63(2):314‑324. doi:10.1002/art.30105 6. Macovei LA, Burlui A, Bratoiu I, et al. Adult-onset Still’s disease—a complex disease, a challenging treatment. Int J Mol Sci. 2022;23(21):12810. doi:10.3390/ijms232112810